Derivatized oxopiperazine rings from amino acids

被引：40

作者：

Bhatt, U

Mohamed, N

Just, G

Roberts, E

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA

[2] ASTRA RES CTR MONTREAL,ST LAURENT,PQ H4S 1Z9,CANADA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(97)00726-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two routes for the synthesis of derivatized oxopiperazines, which may act as constrained peptide mimics, are reported. The syntheses employ reductive amination and sulfonamide approaches for generating N-allylic amino acid ester derivatives and utilizing them for assembling the ring systems. An aspartame analog was prepared using this methodology. (C) 1997 Elsevier Science Ltd.

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页码：3679 / 3682

页数：4

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