Gene duplication and biased functional retention of paralogs in bacterial genomes

被引:135
作者
Gevers, D [1 ]
Vandepoele, K [1 ]
Simillion, C [1 ]
Van de Peer, Y [1 ]
机构
[1] State Univ Ghent VIB, B-9052 Ghent, Belgium
关键词
D O I
10.1016/j.tim.2004.02.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gene duplication is considered an important prerequisite for gene innovation that can facilitate adaptation to changing environments. The analysis of 106 bacterial genome sequences has revealed the existence of a significant number of paralogs. Analysis of the functional classification of these paralogs reveals a preferential enrichment in functional classes that are involved in transcription, metabolism and defense mechanisms. From the organization of paralogs in the genome we can conclude that duplicated genes in bacteria appear to have been mainly created by small-scale duplication events, such as tandem and operon duplications.
引用
收藏
页码:148 / 154
页数:7
相关论文
共 34 条
  • [11] Lineage-specific gene expansions in bacterial and archaeal genomes
    Jordan, IK
    Makarova, KS
    Spouge, JL
    Wolf, YI
    Koonin, EV
    [J]. GENOME RESEARCH, 2001, 11 (04) : 555 - 565
  • [12] Non-orthologous gene displacement
    Koonin, EV
    Mushegian, AR
    Bork, P
    [J]. TRENDS IN GENETICS, 1996, 12 (09) : 334 - 336
  • [13] The balance of driving forces during genome evolution in prokaryotes
    Kunin, V
    Ouzounis, CA
    [J]. GENOME RESEARCH, 2003, 13 (07) : 1589 - 1594
  • [14] Myriads of protein families, and still counting
    Kunin, V
    Cases, I
    Enright, AJ
    de Lorenzo, V
    Ouzounis, CA
    [J]. GENOME BIOLOGY, 2003, 4 (02)
  • [15] Molecular archaeology of the Escherichia coli genome
    Lawrence, JG
    Ochman, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) : 9413 - 9417
  • [16] From gene trees to organismal phylogeny in prokaryotes:: The case of the γ-proteobacteria
    Lerat, E
    Daubin, V
    Moran, NA
    [J]. PLOS BIOLOGY, 2003, 1 (01) : 101 - 109
  • [17] Evolutionary analyses of the human genome
    Li, WH
    Gu, ZL
    Wang, HD
    Nekrutenko, A
    [J]. NATURE, 2001, 409 (6822) : 847 - 849
  • [18] Genetic architecture of thermal adaptation in Escherichia coli
    Riehle, MM
    Bennett, AF
    Long, AD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) : 525 - 530
  • [19] An appraisal of the potential for illegitimate recombination in bacterial genomes and its consequences: From duplications to genome reduction
    Rocha, EPC
    [J]. GENOME RESEARCH, 2003, 13 (06) : 1123 - 1132
  • [20] Twilight zone of protein sequence alignments
    Rost, B
    [J]. PROTEIN ENGINEERING, 1999, 12 (02): : 85 - 94