Synthesis of a novel fluorescent probe for estrogen receptor

被引：10

作者：

Adamczyk, M ^{[1
]}

Reddy, RE ^{[1
]}

Yu, ZG ^{[1
]}

机构：

[1] Abbott Labs, Diagnost Div, Dept Chem, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(02)00144-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERalpha), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1283 / 1285

页数：3

共 31 条

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