Regulation of microRNA processing in development, differentiation and cancer

被引:88
作者
Schmittgen, Thomas D. [1 ]
机构
[1] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA
关键词
microRNA biogenesis; microRNA processing;
D O I
10.1111/j.1582-4934.2008.00483.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
microRNA (miRNA) is a class of small, noncoding, regulatory RNAs. The similar to 21 nt mature miRNA is processed from larger precursor molecules following a coordinated series of events. In theory, miRNA processing may be regulated at any of these steps. A growing body of evidence has demonstrated various steps in the miRNA biogenesis process for which regulation occurs. RNA editing of miRNA precursors, SNPs or mutations in the miRNA precursors, regulation by RNA binding proteins, alterations in the levels of key processing proteins, as well as a number of unknown mechanisms contribute to the regulation of miRNA processing. This article reviews the available literature on the regulation of miRNA processing that occurs within normal cells, during development or in diseases such as cancer.
引用
收藏
页码:1811 / 1819
页数:9
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