Expression of heme oxygenase-1 is associated with abortion caused by Brucella abortus infection in pregnant mice

被引：24

作者：

Tachibana, Masato ^{[1
]}

Watanabe, Kenta ^{[1
]}

Yarnasaki, Yuki ^{[1
]}

Suzuki, Hiroshi ^{[2
]}

Watarai, Masahisa ^{[1
]}

机构：

[1] Obihiro Univ Agr & Vet Med, Dept Appl Vet Sci, Obihiro, Hokkaido 0808555, Japan

[2] Obihiro Univ Agr & Vet Med, Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan

来源：

MICROBIAL PATHOGENESIS | 2008年 / 45卷 / 02期

基金：

日本学术振兴会;

关键词：

Brucella abortus; Abortion; HO-1; Placenta;

D O I：

10.1016/j.micpath.2008.04.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brucella abortus is a facultative intracellular pathogen that can survive inside macrophages and trophoblast giant (TG) cells, and the causative agent of brucellosis. In the present study, we found that expression of heme oxygenase-1 (HO-1) in TG cells is correlated with abortion induced by B. abortus infection in pregnant mice. Expression of HO-1 in the placenta was decreased by B. abortus infection and treatment with cobalt-protoporphyrin (Co-PP), which is known to up-regulate HO-1 expression, inhibited abortion due to the bacterial infection. In TG cells, treatment with Co-PP was shown to upregulate HO-1, whereas its expression was decreased by B. abortus infection. Such down-regulation of HO-1 in the TG cells was enhanced by IFN-gamma treatment. HO-I down-regulation in TG cells due to knockdown or IFN-gamma treatment served to induce cell death caused by B. abortus infection. These results suggest that down-regulation of HO-1 in TG cells due to B. abortus infection is an important event in infectious abortion. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：105 / 109

页数：5

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