Sodium dithionite initiated reactions of Halothane® with enol ethers -: Facile synthesis of 3-trifluoromethyl substituted vinyl carbonyl compounds

被引：32

作者：

Plenkiewicz, H ^{[1
]}

Dmowski, W ^{[1
]}

Lipínski, M ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 111卷 / 02期

关键词：

5,5,5-trifluoro-3-penten-2-one; 4,4,4-trifluorocrotonaldehyde; 5,5,5-trifluoro-3-penten-2-ol; 4,4,4-trifluorocrotonic acid; 1-bromo-1-chloro-2,2,2-trifluoroethane; sodium dithionite; enol ethers;

D O I：

10.1016/S0022-1139(01)00459-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A convenient and simple method has been found for the preparation of 5,5,5-trifluoro-3-penten-2-one (3) and 4,4,4-trifluorocrotonaldehyde (9) by a sodium dithionite initiated addition of 1-bromo-1-chloro-2,2,2-trifluoroethane to 2-methoxypropene and ethyl vinyl ether, respectively. Reduction of 3 with aluminium isopropoxide afforded allyl alcohol, 5,5,5-trifluoro-3-penten-2-ol (5) and oxidation of 9 gave 4,4,4-trifluorocrotonic acid (11). (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：227 / 232

页数：6

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