Nanomechanical biosensors: a new sensing tool

被引：206

作者：

Carrascosa, LG ^{[1
]}

Moreno, M ^{[1
]}

Alvarez, M ^{[1
]}

Lechuga, LM ^{[1
]}

机构：

[1] CSIC Isaac Newton, CNM, IMM, Biosensors Grp, E-28760 Madrid, Spain

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2006年 / 25卷 / 03期

关键词：

biomolecular interaction; biosensor; cantilever; fabrication; nanomechanics;

D O I：

10.1016/j.trac.2005.09.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Biosensors based on microcantilevers have become a promising tool for directly detecting biomolecular interactions with great accuracy. Microcantilevers translate molecular recognition of biomolecules into nanomechanical motion that is commonly coupled to an optical or piezo-resistive read-out detector system. Riosensors based on cantilevers are a good example of how nanotechnology and biotechnology can go together. High-throughput platforms using arrays of cantilevers have been developed for simultaneous measurement and read-out of hundreds of samples. As a result, many interesting applications have been performed and the first sensor platforms are being commercialized. This review covers the basic working principles and the types of sensor format, the fabrication and the reported applications in chemical and biological analysis, trends in cantilever fabrication, examples of the commercial instrumentation available, and future developments. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：196 / 206

页数：11

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