An efficient method for the preparation of chiral Mosher's acid analogues

被引：20

作者：

Kawano, Y

Kaneko, N

Mukaiyama, T

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Inst, Ctr Basic Res, Kita Ku, Tokyo 1140003, Japan

来源：

CHEMISTRY LETTERS | 2006年 / 35卷 / 03期

关键词：

D O I：

10.1246/cl.2006.304

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diastereoselective trifluoromethylation of chiral alpha-keto esters derived from isosorbide with TMSCF3 in the presence of a Lewis-base catalyst gave the corresponding trifluoromethylated alpha-hydroxy esters in good yields with moderate to high diastereomeric excesses.

引用

收藏

页码：304 / 305

页数：2

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