Binding of DNA Nucleobases and Nucleosides with Graphene

被引：463

作者：

Varghese, Neenu ^{[1
,2
]}

Mogera, Umesha ^{[1
,2
]}

Govindaraj, Achutharao ^{[1
,2
]}

Das, Anindya ^{[3
]}

Maiti, Prabal K. ^{[3
]}

Sood, Ajay K. ^{[3
]}

Rao, C. N. R. ^{[1
,2
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, Chem & Phys Mat Unit, DST Nanosci Unit, Bangalore 560064, Karnataka, India

[2] Jawaharlal Nehru Ctr Adv Sci Res, CSIR Ctr Excellence Chem, Bangalore 560064, Karnataka, India

[3] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India

来源：

CHEMPHYSCHEM | 2009年 / 10卷 / 01期

关键词：

graphene; isothermal titration calorimetry; nanotubes; nucleobases; nucleosides; ISOTHERMAL TITRATION CALORIMETRY; GENERALIZED BORN MODEL; CARBON NANOTUBES; ADSORPTION; BASES;

D O I：

10.1002/cphc.200800459

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Interaction of two different samples of graphene with DNA nucleobases and nucleosides is investigated by isothermal titration calorimetry. The relative interaction energies of the nucleobases decrease in the order guanine (G) > adenine (A) > cytosine (C) > thy mine (T) in aqueous solutions, although the positions of C and T seem to be interchangeable. The same trend is found with the nucleosides. Interaction energies of the A-T and G-C pairs are somewhere between those of the constituent bases. Theoretical calculations including van der Wools interaction and solvation energies give the trend G > A similar to T > C. The magnitudes of the interaction energies of the nucleobases with graphene are similar to those found with single-walled carbon nonotubes.

引用

页码：206 / 210

页数：5

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