Adolescent impulsivity phenotypes characterized by distinct brain networks

被引：315

作者：

Whelan, Robert ^{[1
,2
]}

Conrod, Patricia J. ^{[3
,4
]}

Poline, Jean-Baptiste ^{[5
]}

Lourdusamy, Anbarasu ^{[3
]}

Banaschewski, Tobias

Barker, Gareth J. ^{[3
]}

Bellgrove, Mark A. ^{[7
,8
]}

Buechel, Christian ^{[9
]}

Byrne, Mark ^{[2
]}

Cummins, Tarrant D. R. ^{[6
,7
,8
]}

Fauth-Buehler, Mira ^{[10
]}

Flor, Herta ^{[11
]}

Gallinat, Juergen ^{[12
]}

Heinz, Andreas ^{[12
]}

Ittermann, Bernd ^{[13
]}

Mann, Karl ^{[10
]}

Martinot, Jean-Luc ^{[14
,15
]}

Lalor, Edmund C. ^{[2
]}

Lathrop, Mark ^{[16
]}

Loth, Eva ^{[3
,17
]}

Nees, Frauke ^{[11
]}

Paus, Tomas ^{[18
,19
,20
]}

Rietschel, Marcella ^{[21
]}

Smolka, Michael N. ^{[22
,23
]}

Spanagel, Rainer ^{[24
]}

Stephens, David N. ^{[25
]}

Struve, Maren ^{[11
]}

Thyreau, Benjamin ^{[5
]}

Vollstaedt-Klein, Sabine ^{[10
]}

Robbins, Trevor W. ^{[26
,27
]}

Schumann, Gunter ^{[3
,17
]}

Garavan, Hugh ^{[1
,2
]}

机构：

[1] Univ Vermont, Dept Psychiat & Psychol, Burlington, VT 05405 USA

[2] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland

[3] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

[4] Univ Montreal, Dept Psychiat, CHU Ste Justine Hosp, Montreal, PQ H3C 3J7, Canada

[5] Neurospin, Commissariat Energie Atom, Gif Sur Yvette, France

[6] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-6800 Mannheim, Germany

[7] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia

[8] Univ Queensland, Sch Psychol, St Lucia, Qld, Australia

[9] Univ klinikum Hamburg Eppendorf, Hamburg, Germany

[10] Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-6800 Mannheim, Germany

[11] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, D-6800 Mannheim, Germany

[12] Charite, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[13] Physikalisch Tech Bundesanstalt, Berlin, Germany

[14] Univ Paris Sud, INSERM CEA Unit Imaging & Psychiat 1000, Inst Natl Sante & Rech Med, Orsay, France

[15] Univ Paris 05, Assistance Publ Hop Paris, Dept Adolescent Psychopathol & Med, Paris, France

[16] Ctr Natl Genptypage, Evry, France

[17] MRC Social, Genet & Dev Psychiat Ctr, London, England

[18] Univ Toronto, Rotman Res Inst, Toronto, ON, Canada

[19] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England

[20] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[21] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany

[22] Tech Univ, Dept Psychiat & Psychotherapy, Dresden, Germany

[23] Tech Univ, Dept Psychol, Neuroimaging Ctr, Dresden, Germany

[24] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Psychopharmacol, D-6800 Mannheim, Germany

[25] Univ Sussex, Dept Psychol, Brighton BN1 9RH, E Sussex, England

[26] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[27] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[28] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 06期

基金：

英国医学研究理事会;

关键词：

RESPONSE-INHIBITION; INDIVIDUAL-DIFFERENCES; ORBITOFRONTAL CORTEX; DRUG-ADDICTION; ACTIVATION; ATOMOXETINE; CHILDHOOD; DISORDER; BEHAVIOR; AGE;

D O I：

10.1038/nn.3092

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.

引用

页码：920 / U153

页数：8

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