Structurally Refined β-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors

被引：46

作者：

Boettcher, Thomas ^{[1
]}

Sieber, Stephan A. ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 04期

关键词：

beta-lactones; antibiotics; inhibitors; MRSA; virulence; CHEMISTRY; TOXIN; ROLES;

D O I：

10.1002/cbic.200800743

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：663 / 666

页数：4

共 22 条

[11] Medical progress -: Staphylococcus aureus infections [J].

Lowy, FD .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (08) :520-532

[12] In situ click chemistry: Enzyme inhibitors made to their own specifications [J].

Manetsch, R ;

Krasinski, A ;

Radic, Z ;

Raushel, J ;

Taylor, P ;

Sharpless, KB ;

Kolb, HC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (40) :12809-12818

[13] Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection [J].

OCallaghan, RJ ;

Callegan, MC ;

Moreau, JM ;

Green, LC ;

Foster, TJ ;

Hartford, OM ;

Engel, LS ;

Hill, JM .

INFECTION AND IMMUNITY, 1997, 65 (05) :1571-1578

[14] INTERFERENCE OF STAPHYLOCOCCUS-AUREUS LIPASE WITH HUMAN GRANULOCYTE FUNCTION [J].

ROLLOF, J ;

BRACONIER, JH ;

SODERSTROM, C ;

NILSSONEHLE, P .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1988, 7 (04) :505-510

[15] Activity-based protein profiling in vivo using a copper(I)-catalyzed azide-alkyne [3+2] cycloaddition [J].

Speers, AE ;

Adam, GC ;

Cravatt, BF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (16) :4686-4687

[16] Rot repression of enterotoxin B expression in Staphylococcus aureus [J].

Tseng, CW ;

Stewart, GC .

JOURNAL OF BACTERIOLOGY, 2005, 187 (15) :5301-5309

[17]

von Nussbaum F., 2006, Angew. Chem. Int. Ed, V118, P5194, DOI DOI 10.1002/ANGE.200600350

[18] Antibacterial natural products in medicinal chemistry - Exodus or revival? [J].

von Nussbaum, Franz ;

Brands, Michael ;

Hinzen, Berthold ;

Weigand, Stefan ;

Haebich, Dieter .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (31) :5072-5129

[19] Selective killing of human monocytes and cytokine release provoked by Sphingomyelinase (beta-toxin) of Staphylococcus aureus [J].

Walev, I ;

Weller, U ;

Strauch, S ;

Foster, T ;

Bhakdi, S .

INFECTION AND IMMUNITY, 1996, 64 (08) :2974-2979

[20] Inhibitors of HIV-1 protease by using in situ click chemistry [J].

Whiting, M ;

Muldoon, J ;

Lin, YC ;

Silverman, SM ;

Lindstrom, W ;

Olson, AJ ;

Kolb, HC ;

Finn, MG ;

Sharpless, KB ;

Elder, JH ;

Fokin, VV .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (09) :1435-1439

← 1 2 3 →