Fabrication and properties of chitin/hydroxyapatite hybrid hydrogels as scaffold nano-materials

被引：133

作者：

Chang, Chunyu ^{[1
,2
,3
]}

Peng, Na ^{[2
,3
]}

He, Meng ^{[1
]}

Teramoto, Yoshikuni ^{[3
]}

Nishio, Yoshiyuki ^{[3
]}

Zhang, Lina ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[2] Guangzhou Sugarcane Ind Res Inst, Guangzhou 510316, Guangdong, Peoples R China

[3] Kyoto Univ, Grad Sch Agr, Div Forest & Biomat Sci, Sakyo Ku, Kyoto 6068502, Japan

来源：

CARBOHYDRATE POLYMERS | 2013年 / 91卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chitin; Nano-hydroxyapatite; Hybrid hydrogel; Scaffolds; COMPOSITE SCAFFOLDS; HYDROXYAPATITE COMPOSITE; TISSUE; REGENERATION;

D O I：

10.1016/j.carbpol.2012.07.070

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Novel hybrid hydrogels were prepared by introducing nano-hydroxyapatite (nHAp) into chitin solution dissolved in NaOH/urea aqueous solution at low temperature, and then by cross-linking with epichlorohydrin (ECH). Their structure and morphology were characterized by FTIR spectra, wide-angle X-ray diffraction (WAXD), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Our findings revealed that hydroxyapatite nano-particles were uniformly dispersed in chitin hydrogel networks. The chitin/nHAP hybrid hydrogel (Gel2) exhibited about 10 times higher mechanical properties (compressive strength: 274 kPa) than that of chitin hydrogel. Moreover, COS-7 cell culture experiment proved that cells could adhere and proliferate well on the chitin/nHAp hydrogels, suggesting good biocompatibility. All these results signified that these bio-materials could be potential candidates as scaffolds for tissue engineering. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7 / 13

页数：7

共 28 条

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Facile synthesis of anisotropic porous chitosan/hydroxyapatite scaffolds for bone tissue engineering [J].