Oncometabolites: linking altered metabolism with cancer

被引：323

作者：

Yang, Ming ^{[1
]}

Soga, Tomoyoshi ^{[2
,3
]}

Pollard, Patrick J. ^{[1
,4
]}

机构：

[1] Univ Oxford, Canc Biol & Metab Grp, Nuffield Dept Med, Oxford OX3 7BN, England

[2] Keio Univ, Inst Adv Biosci, Yamagata, Japan

[3] Keio Univ, Oxford Keio Metabol Consortium, Yamagata, Japan

[4] Oxford Keio Metabol Consortium, Oxford, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 09期

基金：

欧洲研究理事会;

关键词：

ACUTE MYELOID-LEUKEMIA; ISOCITRATE DEHYDROGENASE 1; HEMATOPOIETIC STEM-CELLS; FUMARATE HYDRATASE; IDH2; MUTATIONS; OXIDATIVE STRESS; ANTIOXIDANT RESPONSE; TUMOR-SUPPRESSOR; COMPLEX-II; CHEMICAL-MODIFICATION;

D O I：

10.1172/JCI67228

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

引用

页码：3652 / 3658

页数：7

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