DNA chips: promising toys have become powerful tools

被引：219

作者：

Gerhold, D ^{[1
]}

Rushmore, T

Caskey, CT

机构：

[1] Merck & Co Inc, Dept Human Genet, W Point, PA 19486 USA

[2] Merck Sharp & Dohme Ltd, Dept Drug Metab, W Point, PA 19486 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(99)01382-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA chips are glass surfaces that represent thousands of DNA fragments arrayed at discrete sites. Hybridization of RNA or DNA-derived samples to DNA chips allows us to monitor expression of mRNAs or the occurrence of polymorphisms in genomic DNA. The technology holds great promise for identifying gene polymorphisms that predispose man to disease, gene regulation events involved in disease progression, and more-effective disease treatments.

引用

页码：168 / 173

页数：6

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