The TissueNet database of human tissue protein-protein interactions

被引：47

作者：

Barshir, Ruth ^{[1
]}

Basha, Omer ^{[1
]}

Eluk, Amir ^{[1
]}

Smoly, Ilan Y. ^{[2
]}

Lan, Alexander ^{[2
]}

Yeger-Lotem, Esti ^{[1
,3
]}

机构：

[1] Ben Gurion Univ Negev, Dept Clin Biochem, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Dept Comp Sci, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Natl Ctr Biotechnol Negev, IL-84105 Beer Sheva, Israel

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

关键词：

SPECIFICITY;

D O I：

10.1093/nar/gks1198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Knowledge of protein-protein interactions (PPIs) is important for identifying the functions of proteins and the processes they are involved in. Although data of human PPIs are easily accessible through several public databases, these databases do not specify the human tissues in which these PPIs take place. The TissueNet database of human tissue PPIs (http://netbio.bgu.ac.il/tissuenet/) associates each interaction with human tissues that express both pair mates. This was achieved by integrating current data of experimentally detected PPIs with extensive data of gene and protein expression across 16 main human tissues. Users can query TissueNet using a protein and retrieve its PPI partners per tissue, or using a PPI and retrieve the tissues expressing both pair mates. The graphical representation of the output highlights tissue-specific and tissue-wide PPIs. Thus, TissueNet provides a unique platform for assessing the roles of human proteins and their interactions across tissues.

引用

页码：D841 / D844

页数：4

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