Molecular typing of Borrelia burgdorferi sensu lato:: Taxonomic, epidemiological, and clinical implications

被引:350
作者
Wang, GQ
van Dam, AP
Schwartz, I
Dankert, J
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands
[2] New York Med Coll, Dept Biochem & Mol Biol, Valhalla, NY 10595 USA
关键词
D O I
10.1128/CMR.12.4.633
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Borrelia burgdorferi sensu lato, the spirochete that causes human Lyme borreliosis (LB), is a genetically and phenotypically divergent species. In the past several years, various molecular approaches have been developed and used to determine the phenotypic and genetic heterogeneity within the LB-related spirochetes and their potential association with distinct clinical syndromes. These methods include serotyping, multilocus enzyme electrophoresis, DNA-DNA reassociation analysis, rRNA gene restriction analysis (ribotyping), pulsed-field gel electrophoresis, plasmid fingerprinting, randomly amplified polymorphic DNA fingerprinting analysis, species-specific PCR and PCR-based restriction fragment length polymorphism (RFLP) analysis, and sequence analysis of 16S rRNA and other conserved genes. On the basis of DNA-DNA reassociation analysis, 10 different Borrelia species have been described within the B. burgdorferi sensu lato complex: B. burgdorferi sensu stricto, Borrelia garinii, Borrelia afzelii, Borrelia japonica, Borrelia andersonii, Borrelia valaisiana, Borrelia lusitaniae, Borrelia tanukii, Borrelia turdi, and Borrelia bissettii sp. nov. To date, only B. burgdorferi sensu stricto, B. garinii, and B. afzelii are well known to be responsible for causing human disease. Different Borrelia species have been associated with distinct clinical manifestations of LB. In addition, Borrelia species are differentially distributed worldwide and may be maintained through different transmission cycles in nature. In this paper, the molecular methods used for typing of B. burgdorferi sensu lato are reviewed. The current taxonomic status of B. burgdorferi sensu lato and its epidemiological and clinical implications, especially correlation between the variable clinical presentations and the infecting Borrelia species, are discussed in detail.
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页码:633 / +
页数:23
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共 292 条
[61]   Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity [J].
Fikrig, E ;
Barthold, SW ;
Sun, W ;
Feng, W ;
Telford, SR ;
Flavell, RA .
IMMUNITY, 1997, 6 (05) :531-539
[62]   PROTECTION OF MICE AGAINST THE LYME-DISEASE AGENT BY IMMUNIZING WITH RECOMBINANT OSPA [J].
FIKRIG, E ;
BARTHOLD, SW ;
KANTOR, FS ;
FLAVELL, RA .
SCIENCE, 1990, 250 (4980) :553-556
[63]   VACCINATION AGAINST LYME-DISEASE CAUSED BY DIVERSE BORRELIA-BURGDORFERI [J].
FIKRIG, E ;
TELFORD, SR ;
WALLICH, R ;
CHEN, MC ;
LOBET, Y ;
MATUSCHKA, FR ;
KIMSEY, RB ;
KANTOR, FS ;
BARTHOLD, SW ;
SPIELMAN, A ;
FLAVELL, RA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :215-221
[64]   Phylogenetic analysis of Borrelia burgdorferi sensu stricto by arbitrarily primed PCR and pulsed-field gel electrophoresis [J].
Foretz, M ;
Postic, D ;
Baranton, G .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1997, 47 (01) :11-18
[65]   Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi [J].
Fraser, CM ;
Casjens, S ;
Huang, WM ;
Sutton, GG ;
Clayton, R ;
Lathigra, R ;
White, O ;
Ketchum, KA ;
Dodson, R ;
Hickey, EK ;
Gwinn, M ;
Dougherty, B ;
Tomb, JF ;
Fleischmann, RD ;
Richardson, D ;
Peterson, J ;
Kerlavage, AR ;
Quackenbush, J ;
Salzberg, S ;
Hanson, M ;
vanVugt, R ;
Palmer, N ;
Adams, MD ;
Gocayne, J ;
Weidman, J ;
Utterback, T ;
Watthey, L ;
McDonald, L ;
Artiach, P ;
Bowman, C ;
Garland, S ;
Fujii, C ;
Cotton, MD ;
Horst, K ;
Roberts, K ;
Hatch, B ;
Smith, HO ;
Venter, JC .
NATURE, 1997, 390 (6660) :580-586
[66]   A phylogenetic analysis of Borrelia burgdorferi sensu lato isolates associated with Lyme disease in Japan by flagellin gene sequence determination [J].
Fukunaga, M ;
Koreki, Y .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1996, 46 (02) :416-421
[67]   Characterization of spirochetes isolated from ticks (Ixodes tanuki, Ixodes turdus, and Ixodes columnae) and comparison of the sequences with those of Borrelia burgdorferi sensu lato strains [J].
Fukunaga, M ;
Hamase, A ;
Okada, H ;
Inoue, H ;
Tsuruta, Y ;
Miyamoto, K ;
Nakao, M .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1996, 62 (07) :2338-2344
[68]   OUTER SURFACE PROTEIN-C GENE SEQUENCE-ANALYSIS OF BORRELIA-BURGDORFERI SENSU-LATO ISOLATES FROM JAPAN [J].
FUKUNAGA, M ;
HAMASE, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (09) :2415-2420
[69]   Borrelia tanukii sp nov and Borrelia turdae sp nov found from ixodid ticks in Japan: Rapid species identification by 16S rRNA gene-targeted PCR analysis [J].
Fukunaga, M ;
Hamase, A ;
Okada, K ;
Nakao, M .
MICROBIOLOGY AND IMMUNOLOGY, 1996, 40 (11) :877-881
[70]   Phylogenetic analysis of Borrelia species based on flagellin gene sequences and its application for molecular typing of Lyme disease borreliae [J].
Fukunaga, M ;
Okada, K ;
Nakao, M ;
Konishi, T ;
Sato, Y .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1996, 46 (04) :898-905