miR2Disease: a manually curated database for microRNA deregulation in human disease

被引：1112

作者：

Jiang, Qinghua ^{[1
]}

Wang, Yadong ^{[1
,2
]}

Hao, Yangyang ^{[1
]}

Juan, Liran ^{[1
]}

Teng, Mingxiang ^{[1
]}

Zhang, Xinjun ^{[1
]}

Li, Meimei ^{[1
]}

Wang, Guohua ^{[1
,2
,3
]}

Liu, Yunlong ^{[2
,3
,4
]}

机构：

[1] Harbin Inst Technol, Sch Comp Sci & Technol, Ctr Biomed Informat, Harbin 150001, Heilongjiang, Peoples R China

[2] Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

[3] Indiana Univ, Sch Med, Dept Med, Div Biostat, Indianapolis, IN 46202 USA

[4] Indiana Univ, Sch Med, Ctr Med Genom, Indianapolis, IN 46202 USA

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

中国国家自然科学基金;

关键词：

LUNG-CANCER; REGULATED MICRORNA; DOWN-REGULATION; TUMOR INVASION; BREAST-CANCER; EXPRESSION; MIRNAS; GENE; TARGETS; METASTASIS;

D O I：

10.1093/nar/gkn714

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

'miR2Disease', a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. The current version of miR2Disease documents 1939 curated relationships between 299 human microRNAs and 94 human diseases by reviewing more than 600 published papers. Around one-seventh of the microRNA-disease relationships represent the pathogenic roles of deregulated microRNA in human disease. Each entry in the miR2Disease contains detailed information on a microRNA disease relationship, including a microRNA ID, the disease name, a brief description of the microRNA-disease relationship, an expression pattern of the microRNA, the detection method for microRNA expression, experimentally verified target gene(s) of the microRNA and a literature reference. miR2Disease provides a user-friendly interface for a convenient retrieval of each entry by microRNA ID, disease name, or target gene. In addition, miR2Disease offers a submission page that allows researchers to submit established microRNA disease relationships that are not documented. Once approved by the submission review committee, the submitted records will be included in the database. miR2Disease is freely available at http://www.miR2Disease.org.

引用

页码：D98 / D104

页数：7

共 53 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].