Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

被引：22

作者：

Cammas, Anne ^{[2
,3
,4
]}

Lewis, Stephen M. ^{[1
,5
]}

Vagner, Stephan ^{[2
,3
,4
]}

Holcik, Martin ^{[1
]}

机构：

[1] Univ Ottawa, Dept Paediat, Childrens Hosp Eastern Ontario, Apoptosis Res Ctr,Res Inst, Ottawa, ON K1H 8L1, Canada

[2] INSERM, U563, F-31000 Toulouse, France

[3] Inst Claudius Regaud, F-31000 Toulouse, France

[4] Univ Toulouse 3, F-31000 Toulouse, France

[5] Atlantic Canc Res Inst, Moncton, NB E1C 8X3, Canada

来源：

BIOCHEMICAL PHARMACOLOGY | 2008年 / 76卷 / 11期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

RNA binding protein; Subcellular localization; Splicing; Translation; IRES; Signaling pathway;

D O I：

10.1016/j.bcp.2008.05.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression. (C) 2008 Elsevier Inc. All rights reserved.

引用

收藏

页码：1395 / 1403

页数：9

相关论文

共 61 条

[21] Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma [J].

Heinonen, M ;

Bono, P ;

Narko, K ;

Chang, SH ;

Lundin, J ;

Joensuu, H ;

Furneaux, H ;

Hla, T ;

Haglund, C ;

Ristimäki, A .

CANCER RESEARCH, 2005, 65 (06) :2157-2161

[22] The yeast hnRNP-like protein Hrp1/Nab4 accumulates in the cytoplasm after hyperosmotic stress: A novel Fps1-dependent response [J].

Henry, MF ;

Mandel, D ;

Routson, V ;

Henry, PA .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (09) :3929-3941

[23] XIAP, the guardian angel [J].

Holcik, M ;

Korneluk, RG .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (07) :550-556

[24] Translational control in stress and apoptosis [J].

Holcik, M ;

Sonenberg, N .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :318-327

[25] SRprises along a messenger's journey [J].

Huang, YQ ;

Steitz, JA .

MOLECULAR CELL, 2005, 17 (05) :613-615

[26] ATP potentiates interleukin-1β-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR [J].

Huwiler, A ;

Akool, ES ;

Aschrafi, A ;

Hamada, FMA ;

Pfeilschifter, J ;

Eberhardt, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :51758-51769

[27] Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export [J].

Kamath, RV ;

Leary, DJ ;

Huang, S .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (12) :3808-3820

[28] cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in β cells [J].

Knoch, KP ;

Meisterfeld, R ;

Kersting, S ;

Bergert, H ;

Altkrüger, A ;

Wegbrod, C ;

Jäger, M ;

Saeger, HD ;

Solimena, M .

CELL METABOLISM, 2006, 3 (02) :123-134

[29] Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis [J].

Knoch, KP ;

Bergert, H ;

Borgonovo, B ;

Saeger, HD ;

Altkrüger, A ;

Verkade, P ;

Solimena, M .

NATURE CELL BIOLOGY, 2004, 6 (03) :207-214

[30] Compartmentalization of hnRNP-K during cell cycle progression and its interaction with calponin in the cytoplasm [J].

Laury-Kleintop, LD ;

Tresini, M ;

Hammond, O .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 95 (05) :1042-1056

← 1 2 3 4 5 6 7 →