Microwave-Assisted Cascade Cycloaddition for C-N Bond Formation: An Approach to the Construction of 1,4,5,6-Tetrahydropyrimidine and 2-Imidazoline Derivatives

被引：12

作者：

An, Shujuan

Yin, Bing

Liu, Ping

Li, Xiangnan

Li, Chen

Li, Jianli ^{[1
]}

Shi, Zhen

机构：

[1] NW Univ Xian, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 18期

基金：

中国国家自然科学基金;

关键词：

catalysis; cycloaddition; nitrogen heterocycles; nitriles; synthesis; TETRAHYDROPYRIMIDINE DERIVATIVES; EFFICIENT SYNTHESIS; 2-ARYL-N-TOSYLAZETIDINES; CATALYST; INDOLES; DESIGN; ACCESS; RINGS;

D O I：

10.1055/s-0033-1339406

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy for the synthesis of various 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives has been reported. The reactions proceeded from nitriles with ethylenediamine or 1,3-diaminopropane via cascade cycloaddition in the presence of CuL2 (L=2-hydroxy-2-phenylacetate) to afford the corresponding 1,4,5,6-tetrahydropyrimidine or 2-imidazoline derivatives under reflux conditions or microwave irradiation in excellent yields.

引用

收藏

页码：2525 / 2532

页数：8

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