Uncatalyzed Mukaiyama-Michael reaction:: Rapid access to simple and complex enantiopure γ-butenolides

被引：18

作者：

Barluenga, J ^{[1
]}

de Prado, A ^{[1
]}

Santamaría, J ^{[1
]}

Tomás, M ^{[1
]}

机构：

[1] Univ Oviedo, CSIC, Unidad Asociada, Inst Univ Quim Organomet Enrique Moles, E-33006 Oviedo, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 40期

关键词：

asymmetric synthesis; carbenes; chirality; diastereoselectivity; lactones;

D O I：

10.1002/anie.200501746

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple start: A tungsten carbene 3, 2-trimethylsilyloxyfuran (4), and an enantiopure aldehyde 5 provide easy access to enantiopure butenolides 2. The metal carbene increases the accepting character of the C=C bond and allows further transformations into butenolide structures such as 1. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：6583 / 6585

页数：3

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