Adult Neurogenesis in Humans

被引：189

作者：

Bergmann, Olaf ^{[1
]}

Spalding, Kirsty L. ^{[1
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2015年 / 7卷 / 07期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

NEURAL STEM-CELLS; ROSTRAL MIGRATORY STREAM; OLFACTORY-BULB VOLUME; PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; HUMAN BRAIN; SUBVENTRICULAR ZONE; DENTATE GYRUS; NEURONS; NUMBER;

D O I：

10.1101/cshperspect.a018994

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adult neurogenesis appears very well conserved among mammals. It was, however, not until recently that quantitative data on the extent of this process became available in humans, largely because of methodological challenges to study this process in man. There is substantial hippocampal neurogenesis in adult humans, but humans appear unique among mammals in that there is no detectable olfactory bulb neurogenesis but continuous addition of new neurons in the striatum.

引用

页数：12

共 74 条

[51]

Palmer TD, 2000, J COMP NEUROL, V425, P479, DOI 10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO

[52]

2-3

[53]

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus [J].

Pereira, Ana C. ;

Huddleston, Dan E. ;

Brickman, Adam M. ;

Sosunov, Alexander A. ;

Hen, Rene ;

McKhann, Guy M. ;

Sloan, Richard ;

Gage, Fred H. ;

Brown, Truman R. ;

Small, Scott A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (13) :5638-5643

[54]

LIMITS OF NEUROGENESIS IN PRIMATES [J].

RAKIC, P .

SCIENCE, 1985, 227 (4690) :1054-1056

[55]

A Nuclear Magnetic Resonance Biomarker for Neural Progenitor Cells: Is It All Neurogenesis? [J].

Ramm, Paul ;

Couillard-Despres, Sebastien ;

Ploetz, Sonja ;

Rivera, Francisco J. ;

Krampert, Monika ;

Lehner, Bernadette ;

Kremer, Werner ;

Bogdahn, Ulrich ;

Kalbitzer, Hans R. ;

Aigner, Ludwig .

STEM CELLS, 2009, 27 (02) :420-423

[56]

Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory [J].

Rochefort, C ;

Gheusi, G ;

Vincent, JD ;

Lledo, PM .

JOURNAL OF NEUROSCIENCE, 2002, 22 (07) :2679-2689

[57]

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation [J].

Sahay, Amar ;

Scobie, Kimberly N. ;

Hill, Alexis S. ;

O'Carroll, Colin M. ;

Kheirbek, Mazen A. ;

Burghardt, Nesha S. ;

Fenton, Andre A. ;

Dranovsky, Alex ;

Hen, Rene .

NATURE, 2011, 472 (7344) :466-U539

[58]

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration [J].

Sanai, N ;

Tramontin, AD ;

Quiñones-Hinojosa, A ;

Barbaro, NM ;

Gupta, N ;

Kunwar, S ;

Lawton, MT ;

McDermott, MW ;

Parsa, AT ;

Verdugo, JMG ;

Berger, MS ;

Alvarez-Buylla, A .

NATURE, 2004, 427 (6976) :740-744

[59]

Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension" [J].

Sanai, Nader ;

Berger, Mitchel S. ;

Garcia-Verdugo, Jose Manuel ;

Alvarez-Buylla, Arturo .

SCIENCE, 2007, 318 (5849) :393b

[60]

Corridors of migrating neurons in the human brain and their decline during infancy [J].

Sanai, Nader ;

Thuhien Nguyen ;

Ihrie, Rebecca A. ;

Mirzadeh, Zaman ;

Tsai, Hui-Hsin ;

Wong, Michael ;

Gupta, Nalin ;

Berger, Mitchel S. ;

Huang, Eric ;

Garcia-Verdugo, Jose-Manuel ;

Rowitch, David H. ;

Alvarez-Buylla, Arturo .

NATURE, 2011, 478 (7369) :382-+

← 1 2 3 4 5 6 7 8 →