PTEN function in mammalian cell size regulation

被引：77

作者：

Backman, SA

Stambolic, V

Mak, TW

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[2] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(02)00354-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3'kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

引用

页码：516 / 522

页数：7

共 69 条

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