Search for Bioactive Natural Products Targeting Cancer-Related Signaling Pathways

被引：20

作者：

Ishibashi, Masami ^{[1
]}

Arai, Midori A. ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2009年 / 67卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

MYXOMYCETE PHYSARUM-MELLEUM; SMALL-MOLECULE ANTAGONISTS; TRAIL-INDUCED APOPTOSIS; QUINIC ACID-ESTERS; CURCUMA-PARVIFLORA; DRUG DISCOVERY; UP-REGULATION; ABSOLUTE STEREOCHEMISTRY; MEDIATED TRANSCRIPTION; MILLETTIA-BRANDISIANA;

D O I：

10.5059/yukigoseikyokaishi.67.1094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

During our studies related to the search for bioactive natural products, we recently examined extracts of various natural resources including unexplored myxomycetes, marine organisms, as well as several medicinal plants collected in the north-eastern part of Thailand and Bangladesh. Here we describe our recent results from our screening programs targeting signaling molecules in cancer-related biological pathways such as TRAIL, Writ, and Hedgehog signalings.

引用

页码：1094 / 1104

页数：11

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