Total synthesis of (±)-rocaglamide and some aryl analogues

被引：56

作者：

Dobler, MR

Bruce, I

Cederbaum, F

Cooke, NG

Diorazio, LJ

Hall, RG

Irving, E

机构：

[1] Novartis Crop Protect AG, CH-4002 Basel, Switzerland

[2] Novartis Pharmaceut, Cent Res, Macclesfield SK10 2NX, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(01)01807-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The insecticidal activity found for rocaglamide and its congeners, prompted us to establish a short and efficient synthesis of the natural product and some synthetic 'halo-aryl' analogues. Pd-catalysed cross-coupling reactions of the bromo analogue were then explored in order to gain a suitable access to a broad range of unnatural analogues. The key step of our approach is a keto-aldehyde acyloin ring-closure followed by a Stiles carboxylation. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8281 / 8284

页数：4

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