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Cytokines and their relationship to the symptoms and outcome of cancer

被引：496
作者：
Seruga, Bostjan [1 ]
Zhang, Haibo [2 ,3 ]
Bernstein, Lori J. [4 ]
Tannock, Ian F. [1 ]
机构：
[1] Univ Toronto, Princess Margaret Hosp, Div Med Oncol, Toronto, ON, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Anaesthesiol, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, St Michaels Hosp, Dept Crit Care Med, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, Princess Margaret Hosp, Dept Psychosocial Oncol & Palliat Care, Toronto, ON, Canada
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 11期
关键词：
D O I：
10.1038/nrc2507
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.
引用
收藏
页码：887 / 899
页数：14
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