Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

被引：782

作者：

Li, Jian-Feng ^{[1
,2
,3
]}

Norville, Julie E. ^{[3
,4
]}

Aach, John ^{[3
,4
]}

McCormack, Matthew ^{[1
,2
,3
]}

Zhang, Dandan ^{[1
,2
,3
]}

Bush, Jenifer ^{[1
,2
,3
]}

Church, George M. ^{[3
,4
]}

Sheen, Jen ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Cambridge, MA 02138 USA

来源：

NATURE BIOTECHNOLOGY | 2013年 / 31卷 / 08期

基金：

美国国家科学基金会;

关键词：

GENE-EXPRESSION; CRISPR; SYSTEMS; NUCLEASES; TALEN;

D O I：

10.1038/nbt.2654

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：688 / 691

页数：5

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