Expedited synthesis of suhstituted dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones structurally related to granulatimide

被引：16

作者：

Hénon, H

Anizon, F

Kucharczyk, N

Loynel, A

Casara, P

Pfeiffer, B

Prudhomme, M ^{[1
]}

机构：

[1] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, CNRS, F-63177 Clermont Ferrand, France

[2] Inst Rech SERVIER, Div Rech Cancerol, F-78290 Croissy Sur Seine, France

来源：

SYNTHESIS-STUTTGART | 2006年 / 04期

关键词：

parallel synthesis; granulatimide; antitumor agents; dipyrrolo[3,4-a : 3,4-c]carbazole-1,3,4,6-tetraone;

D O I：

10.1055/s-2006-926308

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dipyrrolo[3,4-a: 3,4-c]carbazole- 1,3,4,6-tetraones can be considered as granulatimide analogues. In view of structure-activity relationship studies in these series, a parallel liquid-phase microwave-assisted synthesis was developed to generate a small library of compounds bearing various substituents at positions 8, 9, 10, or 11 on the aromatic framework.

引用

页码：711 / 715

页数：5

共 18 条

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Andersen R. J., 1999, Chem. Abstr., Patent No. [WO 9947522A1, 9947522, W099/47522, CA 131: 243451]

[2]

ATOR M, 2001, Patent No. 0185686

[3] Granulatimide and isogranulatimide, aromatic alkaloids with G2 checkpoint inhibition activity isolated from the Brazilian ascidian Didemnum granulatum:: Structure elucidation and synthesis [J].