Application of Ynamides in the Synthesis of 2-Amidoindoles

被引：76

作者：

Dooleweerdt, Karin ^{[2
,3
]}

Ruhland, Thomas ^{[1
]}

Skrydstrup, Troels ^{[2
,3
]}

机构：

[1] H Lundbeck & Co AS, DK-2400 Copenhagen, Denmark

[2] Aarhus Univ, Ctr Insoluble Prot Struct inSPIN, Dept Chem, DK-8000 Aarhus C, Denmark

[3] Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus C, Denmark

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 01期

关键词：

ONE-POT SYNTHESIS; HIGHLY FUNCTIONALIZED INDOLES; AXIALLY CHIRAL ANILIDES; EFFICIENT SYNTHESIS; SUBSTITUTED YNAMIDES; ALKYNYL BROMIDES; O-HALOANILINES; GENERAL-METHOD; ENE-YNAMIDES; CYCLOADDITIONS;

D O I：

10.1021/ol802477d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o-lodoanilines Is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.

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页码：221 / 224

页数：4

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