What Causes Cell Death in Parkinson's Disease?

被引：99

作者：

Gupta, Amitabh ^{[1
]}

Dawson, Valina L. ^{[1
,2
,3
,4
]}

Dawson, Ted M. ^{[1
,2
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA

来源：

ANNALS OF NEUROLOGY | 2008年 / 64卷 / 06期

关键词：

D O I：

10.1002/ana.21573

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration.

引用

页码：S3 / S15

页数：13

共 121 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].

Abeliovich, A ;

Schmitz, Y ;

Fariñas, I ;

Choi-Lundberg, D ;

Ho, WH ;

Castillo, PE ;

Shinsky, N ;

Verdugo, JMG ;

Armanini, M ;

Ryan, A ;

Hynes, M ;

Phillips, H ;

Sulzer, D ;

Rosenthal, A .

NEURON, 2000, 25 (01) :239-252

[2] HtrA2 and Parkinson's disease: think PiNK? [J].

Alnemri, Emad S. .

NATURE CELL BIOLOGY, 2007, 9 (11) :1227-1229

[3] Inhibitors of α-synuclein oligomerization and toxicity:: a future therapeutic strategy for Parkinson's disease and related disorders [J].

Amer, Dena A. M. ;

Irvine, G. Brent ;

El-Agnaf, Omar M. A. .

EXPERIMENTAL BRAIN RESEARCH, 2006, 173 (02) :223-233

[4] DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase [J].

Andres-Mateos, Eva ;

Perier, Celine ;

Zhang, Li ;

Blanchard-Fillion, Beatrice ;

Greco, Todd M. ;

Thomas, Bobby ;

Ko, Han Seok ;

Sasaki, Masayuki ;

Ischiropoulos, Harry ;

Przedborski, Serge ;

Dawson, Ted M. ;

Dawson, Valina L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (37) :14807-14812

[5] Pharmacological prevention of Parkinson disease in Drosophila [J].

Auluck, PK ;

Bonini, NM .

NATURE MEDICINE, 2002, 8 (11) :1185-1186

[6] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].

Auluck, PK ;

Chan, HYE ;

Trojanowski, JQ ;

Lee, VMY ;

Bonini, NM .

SCIENCE, 2002, 295 (5556) :865-868

[7]

Beal MF, 1998, ANN NEUROL, V44, pS110

[8] Coenzyme Q10 as a possible treatment for neurodegenerative diseases [J].

Beal, MF .

FREE RADICAL RESEARCH, 2002, 36 (04) :455-460

[9] Nitrated α-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons [J].

Benner, Eric J. ;

Banerjee, Rebecca ;

Reynolds, Ashley D. ;

Sherman, Simon ;

Pisarev, Vladimir M. ;

Tsiperson, Vladislav ;

Nemachek, Craig ;

Ciborowski, Pawel ;

Przedborski, Serge ;

Mosley, R. Lee ;

Gendelman, Howard E. .

PLOS ONE, 2008, 3 (01)

[10] Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].

Betarbet, R ;

Sherer, TB ;

MacKenzie, G ;

Garcia-Osuna, M ;

Panov, AV ;

Greenamyre, JT .

NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306

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