A chromene and prenylated benzoic acid from Piper aduncum

被引：73

作者：

Baldoqui, DC

Kato, MJ

Cavalheiro, AJ

Bolzani, VD

Young, MCM

Furlan, M

机构：

[1] Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil

[2] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo, Brazil

[3] Inst Bot, Secao Fisiol & Bioquim Plantas, BR-01051 Sao Paulo, Brazil

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

Piper aduncum; Piperaceae; chromenes; prenylated benzoic acid; dihydrochalcone; nerolidol; DNA-damaging activity;

D O I：

10.1016/S0031-9422(99)00132-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to nerolidol, 2',6'-dihydroxy-4'-methoxydihydrochalcone, methyl 2,2-dimethyl-8-(3'-methyl-2'-butenyl)-2H-1-chromene-6-carboxylate, methyl 2,2-dimethyl-2H-1-chromene-6-carboxylate and methyl 8-hydroxy-2,2-dimethyl-2H-1-chromene-6-carboxylate, two new natural products were isolated from the leaves of Piper aduncum, 2,2-dimethyl-2H-1-chromene-6-carboxylic acid and 3-(3',7'-dimethyl-2',6 '-octadienyl)-4-methoxybenzoic acid. The structures of the isolates were established based on analysis of spectroscopic data, including ES-MS. The DNA-damaging activity of the isolated compounds was also investigated against mutant strains of Saccharomyces cerevisiae. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：899 / 902

页数：4

共 14 条

[1] Antifungal amide from leaves of Piper hispidum [J].