Three-dimensional cellular-level imaging using full-field optical coherence tomography

被引：108

作者：

Dubois, A ^{[1
]}

Moneron, G ^{[1
]}

Grieve, K ^{[1
]}

Boccara, AC ^{[1
]}

机构：

[1] CNRS, UPR A0005, Lab Opt Phys, Ecole Super Phys & Chim Ind, F-75231 Paris 5, France

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2004年 / 49卷 / 07期

关键词：

D O I：

10.1088/0031-9155/49/7/010

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An ultrahigh-resolution full-field optical coherence tomography (OCT) system has been developed for cellular-level imaging of biological media. The system is based on a Linnik interference microscope illuminated with a tungsten halogen lamp, associated with a high-resolution CCD camera. En face tomographic images are produced in real time, with the best spatial resolution ever achieved in OCT (0.7 mum x 0.9 mum, axial x transverse). A shot-noise limited detection sensitivity of 80 dB can be reached with an acquisition time per image of 1 s. Images of animal ophthalmic biopsies and vegetal tissues are shown.

引用

页码：1227 / 1234

页数：8

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