New Vessels after Stroke: Postischemic Neovascularization and Regeneration

被引：77

作者：

Liman, T. G. ^{[1
]}

Endres, M.

机构：

[1] Charite, Neurol Klin & Poliklin, DE-10117 Berlin, Germany

来源：

CEREBROVASCULAR DISEASES | 2012年 / 33卷 / 05期

关键词：

Acute ischemic stroke; Neovascularization; Endothelial progenitor cells; Angiogenesis; Regeneration; ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE SYNTHASE; ACUTE ISCHEMIC-STROKE; CIRCULATING CD34-POSITIVE CELLS; BONE-MARROW; ENHANCES ANGIOGENESIS; CARDIOVASCULAR RISK; CEREBRAL-ISCHEMIA; ADULT BRAIN; MOBILIZATION;

D O I：

10.1159/000337155

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The formation of new blood vessels after acute ischemic stroke is one of the most promising approaches to future therapies in the emerging field of stroke medicine. Angiogenesis and postnatal vasculogenesis are the underlying mechanisms of the formation of new blood vessels. Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play an important role in neovascularization and during the regenerative processes after a vascular injury as well as in the maintenance of endothelial integrity. This review summarizes possible mechanisms of angiogenesis, postischemic neovascularization and regeneration with a focus on the potential role of EPCs as a risk marker and as a therapeutic target in stroke medicine. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：492 / 499

页数：8

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