Cope rearrangement of Δ3,8-taxane tricarbocycles:: Remarkable solvent effect on product distribution.

被引：6

作者：

Kusama, H ^{[1
]}

Morihira, K ^{[1
]}

Nishimori, T ^{[1
]}

Nakamura, T ^{[1
]}

Kuwajima, I ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 22期

关键词：

rearrangements; dienes; solvents and solvent effects; taxoids;

D O I：

10.1016/S0040-4039(99)00684-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cope rearrangement of the taxane-like tricyclic compounds having a 1,5-diene moiety readily takes place to give novel spirocyclic compounds, This transformation is found to be reversible and the product distribution is greatly dependent on the solvent polarity: the reactions in chloroform afford the taxane-like tricarbocycles, while those in methanol give the spirocyclic compounds exclusively. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：4235 / 4238

页数：4

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