Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies

被引:71
作者
Karpiouk, Andrei B. [1 ]
Aglyamov, Salavat R. [1 ,2 ]
Mallidi, Srivalleesha [1 ]
Shah, Jignesh [1 ]
Scott, W. Guy [3 ]
Rubin, Jonathan M. [4 ]
Emelianov, Stanislav Y. [1 ]
机构
[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
[2] Russian Acad Sci, Inst Math Problems Biol, Pushchino 142290, Moscow Region, Russia
[3] WinProbe Corp, N Palm Beach, FL 33408 USA
[4] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
photoacoustics; ultrasound; imaging; optical properties; deep venous thrombosis; blood clot;
D O I
10.1117/1.2992175
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Treatment of deep venous thrombosis (DVT)-a primary cause of potentially fatal pulmonary embolism (PE)-depends on the age of the thrombus. The existing clinical imaging methods are capable of visualizing a thrombus but cannot determine the age of the blood clot. Therefore, there is a need for an imaging technique to reliably diagnose and adequately stage DVT. To stage DVT (i.e.,to determine the age of the thrombus, and therefore, to differentiate acute from chronic DVT), we explored photoacoustic imaging, a technique capable of noninvasive measurements of the optical absorption in tissue. Indeed, optical absorption of the blood clot changes with age, since maturation of DVT is associated with significant cellular and molecular reorganization. The ultrasound and photoacoustic imaging studies were performed using DVT-mimicking phantoms and phantoms with embedded acute and chronic thrombi obtained from an animal model of DVT. The location and structure of the clots were visualized using ultrasound imaging, while the composition, and therefore age, of thrombi were related to the magnitude and spatio-temporal characteristics of the photoacoustic signal. Overall, the results of our study suggest that combined ultrasound and photoacoustic imaging of thrombi may be capable of simultaneous detection and staging of DVT. (C) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.2992175]
引用
收藏
页数:8
相关论文
共 36 条
[21]   Laser optoacoustic imaging of breast cancer in vivo [J].
Oraevsky, AA ;
Karabutov, AA ;
Solomatin, SV ;
Savateeva, EV ;
Andreev, VG ;
Gatalica, Z ;
Singh, H ;
Fleming, RD .
BIOMEDICAL OPTOACOUSTICS II, 2001, 4256 :6-15
[22]   Doppler ultrasonography versus venography in the detection of deep vein thrombosis in patients with pulmonary embolism [J].
Özbudak, Ö ;
Erogullari, I ;
Ögus, C ;
Çilli, A ;
Türkay, M ;
Özdemir, T .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2006, 21 (02) :159-162
[23]   PULSED OPTOACOUSTIC SPECTROSCOPY OF CONDENSED MATTER [J].
PATEL, CKN ;
TAM, AC .
REVIEWS OF MODERN PHYSICS, 1981, 53 (03) :517-550
[24]   Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry [J].
Pogue, Brian W. ;
Patterson, Michael S. .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (04)
[25]  
PRAHL S, 2000, TABULATED MOLAR EXTI
[26]   Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis - Preliminary findings [J].
Rubin, JM ;
Aglyamov, SR ;
Wakefield, TW ;
O'Donnell, M ;
Emelianov, SY .
JOURNAL OF ULTRASOUND IN MEDICINE, 2003, 22 (05) :443-448
[27]   The accuracy of MRI in diagnosis of suspected deep vein thrombosis: systematic review and meta-analysis [J].
Sampson, Fiona C. ;
Goodacre, Steve W. ;
Thomas, Steven M. ;
van Beek, Edwin J. R. .
EUROPEAN RADIOLOGY, 2007, 17 (01) :175-181
[28]   Diagnosis and treatment of deep-vein thrombosis [J].
Scarvelis, Dimitrios ;
Wells, Philip S. .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2006, 175 (09) :1087-1092
[29]   Ultrasound imaging findings of femoral veins in patients with renal failure and its impact on vascular access [J].
Seyahi, N ;
Kahveci, A ;
Altiparmak, MR ;
Serdengecti, K ;
Erek, E .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2005, 20 (09) :1864-1867
[30]   Radiolabeled peptides in the detection of deep venous thrombosis [J].
Taillefer, R .
SEMINARS IN NUCLEAR MEDICINE, 2001, 31 (02) :102-123