Speculation on the lineage relationships among CD4-8+ gut-derived T cells and their role(s)

被引：15

作者：

Poussier, P ^{[1
]}

Julius, M

机构：

[1] Univ Toronto, Dept Med, Arthrit & Immune Disorder Res Ctr, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Immunol, Arthrit & Immune Disorder Res Ctr, Toronto, ON M5S 1A8, Canada

来源：

SEMINARS IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

intestine-derived T cells; development; selection; lineage relationships; p56(lck);

D O I：

10.1006/smim.1999.0185

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCR gamma delta or TCR alpha beta. Here we discuss the role of MHC in the development and selection of gut-derived T cells. Through the analysis of iIEL selection in animals expressing a transgenic TCR alpha beta, in the presence or absence of p56(lck), we discuss lineage relationships among CD4(-)8(+) iIEL subsets, and their possible function(s).

引用

页码：293 / 303

页数：11

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