Interferon signalling network in innate defence

被引：483

作者：

Takaoka, A ^{[1
]}

Yanai, H ^{[1
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CELLULAR MICROBIOLOGY | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1111/j.1462-5822.2006.00716.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence revealed that not only the first identified Jak-Stat pathway but also other newly found signalling pathways are required for the induction of versatile responses by IFNs. In particular, type I IFNs are inducible by viral infection through the recognition of pathogen-associated molecules by pattern recognition receptors, and the induction of multiple IFN-stimulated genes through the activation of type I IFN signalling confers antiviral and immunomodulatory activities. Any step in this process is often targeted by viruses for their immuno-evasion. The regulatory function of constitutive IFN-alpha/beta signalling has been recognized in terms of its boosting effect on cellular responsiveness in host defence systems. Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications.

引用

页码：907 / 922

页数：16

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