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Telomere structure and function in trypanosomes: a proposal

被引：48
作者：
Dreesen, Oliver
Li, Bibo
Cross, George A. M.
机构：
[1] Rockefeller Univ, New York, NY 10021 USA
[2] Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrmicro1577
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Telomeres are specialized DNA - protein complexes that stabilize chromosome ends, protecting them from nucleolytic degradation and illegitimate recombination. Telomeres form a heterochromatic structure that can suppress the transcription of adjacent genes. These structures might have additional roles in Trypanosoma brucei, as the major surface antigens of this parasite are expressed during its infectious stages from subtelomeric loci. We propose that the telomere protein complexes of trypanosomes and vertebrates are conserved and offer the hypothesis that growth and breakage of telomeric repeats has an important role in regulating parasite antigenic variation in trypanosomes.
引用
收藏
页码：70 / 75
页数：6
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