Synthesis of multisubstituted quinolines from Baylis-Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity

被引：154

作者：

Narender, P.

Srinivas, U.

Ravinder, M.

Rao, B. Ananda

Ramesh, Ch.

Harakishore, K.

Gangadasu, B.

Murthy, U. S. N.

Rao, V. Jayathirtha

机构：

[1] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Organ Chem 2, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 13期

关键词：

substituted; 2-chloronicotinaldehydes; Baylis-Hillman adducts; S(N)2 '-SNAr elimination reaction; multisubstituted quinolines; antimicrobial evaluation;

D O I：

10.1016/j.bmc.2006.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-SNAr elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4600 / 4609

页数：10

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