A Topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxy-pyran-2-ones

被引：13

作者：

Steinbaugh, BA

Hamilton, HW

Prasad, JVNV

Para, KS

Tummino, PJ

Ferguson, D

Lunney, EA

Blankley, CJ

机构：

[1] Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 10期

关键词：

D O I：

10.1016/0960-894X(96)00180-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made. (C) 1996 Elsevier Science Ltd

引用

页码：1099 / 1104

页数：6

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