Mechanisms that Regulate Stem Cell Aging and Life Span

被引：266

作者：

Signer, Robert A. J. ^{[1
]}

Morrison, Sean J. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Childrens Res Inst, Dallas, TX 75390 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

CELL STEM CELL | 2013年 / 12卷 / 02期

基金：

加拿大健康研究院;

关键词：

DNA-DAMAGE RESPONSE; INSULIN-LIKE SIGNALS; SELF-RENEWAL; CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; TELOMERE DYSFUNCTION; TUMOR SUPPRESSION; DIETARY RESTRICTION; MTOR COMPLEX; INK4A LOCUS;

D O I：

10.1016/j.stem.2013.01.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

引用

页码：152 / 165

页数：14

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