Dynamic kinetic resolution of γ-hydroxy acid derivatives

被引：46

作者：

Runmo, ABL

Pàmies, O

Faber, K

Bäckvall, JE ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

[2] Graz Univ, Dept Organ & Bioorgan Chem, A-8010 Graz, Austria

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(02)00418-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enzymatic resolution and dynamic kinetic resolution of gamma-hydroxy acid derivatives 1 have been investigated. Efficient kinetic resolution was obtained using Pseudomonas cepacia lipase in toluene (E value similar to400). The combination of enzymatic kinetic resolution with a ruthenium-catalyzed racemization resulted in an efficient dynamic kinetic resolution. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates in good yield (up to 93%) and enantioselectivity (up to 99%). (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2983 / 2986

页数：4

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