Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells

被引：16

作者：

Li, Hong ^{[1
,2
]}

Mo, Juan ^{[2
]}

Jia, Guizhi ^{[2
]}

Liu, Chao ^{[2
]}

Luan, Zhidong ^{[2
]}

Guan, Yifu ^{[1
]}

机构：

[1] China Med Univ, Dept Biochem & Mol Biol, Shenyang 110001, Liaoning, Peoples R China

[2] Liaoning Med Univ, Dept Biochem & Mol Biol, Jinzhou 121000, Liaoning, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2013年 / 7卷 / 06期

关键词：

BGC-823; Notch1; Wnt/beta-catenin; cell proliferation; gastric cancer; PATHWAY; PROLIFERATION; PROGRESSION; EXPRESSION;

D O I：

10.3892/mmr.2013.1412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Notch and Wnt signaling play critical roles in the regulation of development and diseases. Several studies have previously reported that Notch may be a therapeutic target in the treatment of various types of human cancer. In this study, we report that activation of Notch1 inhibits the proliferation of BGC-823 gastric cancer cells. However, the activation of the Wnt/beta-catenin signaling pathway promotes the growth of BGC-823 cells. Furthermore, the combinational activation of the two signaling pathways promotes the proliferation of BGC-823 cells. These data suggest that the activation of Wnt signaling overcomes the pro-apoptotic role of Notch in BGC-823 gastric cancer cells.

引用

收藏

页码：1751 / 1756

页数：6

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