Recent advance in transition-metal-mediated trifluoromethylation for the construction of C(sp3)-CF3 bonds

被引：129

作者：

Xu, Jun ^{[1
]}

Liu, Xiaoyang ^{[1
]}

Fu, Yao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, Hefei 230026, Peoples R China

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 03期

关键词：

Trifluoromethylation; C(sp(3))-CF3 bonds; Transition-metal-catalyzed; Transition-metal-promoted; COPPER-CATALYZED TRIFLUOROMETHYLATION; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; C-H; NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; TERMINAL ALKENES;

D O I：

10.1016/j.tetlet.2013.11.108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the past 5 years, transition-metal-mediated trifluoromethylation for the construction of various CF3-containing building blocks has been the focus of recent research in both industrial and academic communities. Progresses in the construction of C(sp(2))-CF3 bonds and C(sp)-CF3 have been well reviewed. This Letter will focus on the cases of transition-metal-mediated C(sp(3))-CF3 bond formation, which involves the trifluoromethylation of sp(3)-hybridized C-X bonds, alkyl organometallic reagents, sp(3)-hybridized C-H bonds, and alkene derivatives. (C) 2013 Published by Elsevier Ltd.

引用

页码：585 / 594

页数：10

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