Antigen-receptor degeneracy and immunological paradigms

被引：25

作者：

Cohen, IR ^{[1
]}

Hershberg, U

Solomon, S

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Hebrew Univ Jerusalem, Interdisciplinary Ctr Neuronal Computat, Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 40卷 / 14-15期

基金：

以色列科学基金会;

关键词：

T cells; T-cell receptor; inflammation; specificity; degeneracy; clonal selection; cognitive paradigm;

D O I：

10.1016/j.molimm.2003.11.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：993 / 996

页数：4

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