Mid-IR (3.8-3.9 mu m) interband cascade lasers based on InAs/GaInSb heterostructures have been demonstrated at temperatures up to 210K. The authors have observed a peak optical output power of similar to 2W/facet from one device at 80K, and from another device at 150K, a slope of 735mW/A per facet, corresponding to a differential external quantum efficiency of 456%.