Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

被引：103

作者：

Parolo, Claudio ^{[1
]}

Medina-Sanchez, Mariana ^{[1
]}

de la Escosura-Muniz, Alfredo ^{[1
]}

Merkoci, Arben ^{[1
,2
]}

机构：

[1] CIN2 ICN CSIC, Inst Catala Nanotecnol, Nanobioelect & Biosensors Grp, Barcelona, Spain

[2] ICREA, Barcelona, Spain

来源：

LAB ON A CHIP | 2013年 / 13卷 / 03期

关键词：

BIOSENSOR; LABEL; ASSAY;

D O I：

10.1039/c2lc41144j

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.

引用

页码：386 / 390

页数：5

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