Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain

被引：20

作者：

Nagata, T ^{[1
]}

Aoshi, T ^{[1
]}

Suzuki, M ^{[1
]}

Uchijima, M ^{[1
]}

Kim, YH ^{[1
]}

Yang, ZB ^{[1
]}

Koide, Y ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Microbiol & Immunol, Hamamatsu, Shizuoka 4313192, Japan

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 05期

关键词：

D O I：

10.1128/IAI.70.5.2676-2680.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by a Listeria Th epitope. Immunization of C3H/He mice Both an Ii-LLO 215-226 plasmid induced specific interferon-gamma- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.

引用

页码：2676 / 2680

页数：5

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