Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM

被引：40

作者：

Lu, K ^{[1
]}

Huang, MW ^{[1
]}

Xiang, Z ^{[1
]}

Liu, YX ^{[1
]}

Chen, JH ^{[1
]}

Yang, Z ^{[1
]}

机构：

[1] Peking Univ, Key Lab Bioorgan Chem & Mol Engn,Lab Chem Genet, Minist Educ,Sch Pharmaceut Sci,Shenzhen Grad Sch, Coll Chem,State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1021/ol060221v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.

引用

收藏

页码：1193 / 1196

页数：4

相关论文

共 58 条

[41] Inhibition of mitogen-induced DNA synthesis by bafilomycin A(1) in Swiss 3T3 fibroblasts [J].

Saurin, AJ ;

Hamlett, J ;

Clague, MJ ;

Pennington, SR .

BIOCHEMICAL JOURNAL, 1996, 313 :65-70

[42] Total synthesis of (-)-bafilomycin A1 [J].

Scheidt, KA ;

Bannister, TD ;

Tasaka, A ;

Wendt, MD ;

Savall, BM ;

Fegley, GJ ;

Roush, WR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (24) :6981-6990

[43]

Schuster M, 1997, ANGEW CHEM INT EDIT, V36, P2037

[44] THE STRUCTURE OF A NEW ANTIBIOTIC, HYGROLIDIN [J].

SETO, H ;

AKAO, H ;

FURIHATA, K ;

OTAKE, N .

TETRAHEDRON LETTERS, 1982, 23 (26) :2667-2670

[45] THE ISOLATION AND STRUCTURES OF HYGROLIDIN AMIDE AND DEFUMARYLHYGROLIDIN [J].

SETO, H ;

TAJIMA, I ;

AKAO, H ;

FURIHATA, K ;

OTAKE, N .

JOURNAL OF ANTIBIOTICS, 1984, 37 (05) :610-613

[46] Synthetic studies on V-ATPase inhibiting macrolide antibiotics [J].

Toshima, K .

CURRENT ORGANIC CHEMISTRY, 2004, 8 (02) :185-210

[47] The first total synthesis of concanamycin F (concanolide A) [J].

Toshima, K ;

Jyojima, T ;

Miyamoto, N ;

Katohno, M ;

Nakata, M ;

Matsumura, S .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (05) :1708-1715

[48] Total synthesis of bafilomycin A(1) [J].

Toshima, K ;

Jyojima, T ;

Yamaguchi, H ;

Noguchi, Y ;

Yoshida, T ;

Murase, H ;

Nakata, M ;

Matsumura, S .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (10) :3271-3284

[49] The development of L2X2Ru=CHR olefin metathesis catalysts:: An organometallic success story [J].

Trnka, TM ;

Grubbs, RH .

ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (01) :18-29

[50] 3-Aminopyrrolidines via ring rearrangement of 2-aminomethylazetidines. Synthesis of(-)-absouline [J].

Vargas-Sanchez, M ;

Couty, F ;

Evano, G ;

Prim, D ;

Marrot, J .

ORGANIC LETTERS, 2005, 7 (26) :5861-5864

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