Staurosporine derivatives from the ascidian Eudistoma toealensis and its predatory flatworm Pseudoceros sp.

被引：60

作者：

Schupp, P

Eder, C

Proksch, P

Wray, V

Schneider, B

Herderich, M

Paul, V

机构：

[1] Julius von Sachs Inst Biowissensch, Lehrstuhl Pharmazeut Biol, D-97082 Wurzburg, Germany

[2] Gesell Biotechnol Forsch GmbH, D-38124 Braunschweig, Germany

[3] Max Planck Inst Chem Okol, D-07745 Jena, Germany

[4] Inst Pharm & Lebensmittelchem, Lehrstuhl Lebensmittelchem, D-97074 Wurzburg, Germany

[5] Univ Guam, Marine Lab, UOG, Mangilao, GU 96923 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 07期

关键词：

D O I：

10.1021/np980527d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new indolocarbazole alkaloids, 3-hydroxy-3'-demethoxy-3'-hydroxystaurosporine (5) and 11-hydroxy-4'-N-demethylstaurosporine (6), were isolated from the marine ascidian Eudistoma toealensis and its predator, the marine flatworm Pseudoceros sp. In addition, five known derivatives were isolated in their protonated states, which caused the pyran-ring system to adopt a boat conformation. The structures were determined by 1D and 2D homonuclear and H-1-detected heteronuclear NMR spectroscopy and from comparisons with published data. The heteronuclear correlations were necessary to establish reliable data for the structure elucidation.

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页码：959 / 962

页数：4

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