共 52 条
Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans
被引:418
作者:
den Braber, Ineke
[1
]
Mugwagwa, Tendai
[2
]
Vrisekoop, Nienke
[1
]
Westera, Liset
[1
]
Mogling, Ramona
[1
]
de Boer, Anne Bregje
[1
]
Willems, Neeltje
[1
]
Schrijver, Elise H. R.
[1
]
Spierenburg, Gerrit
[1
]
Gaiser, Koos
[1
]
Mul, Erik
[3
,4
]
Otto, Sigrid A.
[1
]
Ruiter, An F. C.
[5
]
Ackermans, Mariette T.
[5
]
Miedema, Frank
[1
]
Borghans, Jose A. M.
[1
,2
]
de Boer, Rob J.
[2
]
Tesselaar, Kiki
[1
]
机构:
[1] Univ Med Ctr Utrecht, Dept Immunol, NL-3584 EA Utrecht, Netherlands
[2] Univ Utrecht, NL-3584 CA Utrecht, Netherlands
[3] Univ Amsterdam, Landsteiner Lab, NL-1066 CX Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, NL-1066 CX Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Lab Endocrinol & Radiochem, NL-1105 AZ Amsterdam, Netherlands
来源:
关键词:
EXCISION CIRCLE CONTENT;
HIV-INFECTION;
LIFE-SPAN;
IN-VIVO;
MARROW-TRANSPLANTATION;
HUMAN ADULT;
AGED MICE;
LYMPHOCYTES;
PROLIFERATION;
REPERTOIRE;
D O I:
10.1016/j.immuni.2012.02.006
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men. Aging affected naive T cell maintenance fundamentally differently in mice and men. Whereas the naive T cell pool in mice was almost exclusively sustained by thymus output throughout their lifetime, the maintenance of the adult human naive T cell pool occurred almost exclusively through peripheral T cell division. These findings put constraints on the extrapolation of insights into T cell dynamics from mouse to man and vice versa.
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页码:288 / 297
页数:10
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